Prevent hearing loss in a mouse model of human genetic progressive deafness

Hearing loss is the most common form of sensory loss in humans, and almost half of cases stem from genetic causes. Now, a team led by researchers from Harvard Medical School, the Broad Institute of MIT and Harvard, Massachusetts Eye and Ear, Harvard University and Howard Hughes Medical Institute have successfully used gene editing to prevent hearing loss in a mouse model of human genetic progressive deafness. This is an exciting study that demonstrates the feasibility of a DNA-free, virus-free genome editing strategy for a type of autosomal dominant hearing loss characterized by progressive hair cell loss.

Contact:
David R. Liu, Ph.D.
Director of the Merkin Institute for Transformative Technologies in Healthcare
Broad Institute of MIT and Harvard
Cambridge
Tel. +1 617 714-8808 (direct)
liu@chemistry.harvard.edu

Press release: 12/20/2017

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